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KRIYA Ketamine Research Institute

Clinical Scales

KRIYA Institute believes that it is valuable for all ketamine clinicians to use brief formal measures with their ketamine patients. This is important both for tracking each patient’s clinical progress, and also for data collection purposes. In the future, this data could be de-identified and aggregated from multiple sites to identify new clinical indications for ketamine treatment, to apply for FDA approval for generic ketamine for depression, or to support medical insurance coverage for ketamine treatment.

KRIYA Institute is recommending the following set of clinical measures for ketamine treatment.  Each measure was selected because of its reliability and validity, clinical utility and ease of use, accepted use in research, and availability in the public domain.

DEPRESSION
QIDS – Quick Inventory of Depression Symptoms

ANXIETY
GAD-7 – Generalized Anxiety Disorder 7-Item Scale

SUICIDALITY
C-SSRS – Columbia Suicide Severity Rating Scale

PTSD
PCL-5 – PTSD Checklist for DSM-5

SUBSTANCE USE
NM-ASSIST – NIDA Modified Drug Screen Tool

GLOBAL IMPRESSION
CGI – Clinical Global Impression

DISSOCIATION
DES-B – Brief Dissociative Experiences Scales


Here are some additional options:

DEPRESSION
PHQ-9 – Patient Health Questionnaire
HAM-D – Hamilton Depression Rating Scale
MADRS – Montgomery-Asberg Depression Rating Scale
BDI – Beck Depression Inventory

BIPOLAR DISORDER
MDQ  – Mood Disorder Questionnaire
BSDS – Bipolar Spectrum Diagnostic Scale
BDSF – Bipolar Disorder Symptoms and Functioning Monitoring Form
YMRS – Young Mania Rating Scale

ANXIETY
HAM-A – Hamilton Anxiety Rating Scale
BAI – Beck Anxiety Inventory

SUICIDALITY
S-STS – Sheehan Suicide Tracking Scale

PTSD
CAPS-5 – Clinician-Administered PTSD Scale

DISSOCIATION
DSPS – Dissociative Subtype of PTSD Scale
CADSS – Clinican Administered Dissociative States Scale

MYSTICAL EXPERIENCE
5D-ASC – 5-Dimension Altered States of Consciousness Questionnaire
MEQ-30 – Revised Mystical Experience Questionnaire
EDI – Ego-Dissolution Inventory

OTHER
SDS – Sheehan Disability Scale

Many thanks to Christian Yavorsky, Ph.D. and Kelley O’Donnell, M.D. for compiling the original list.

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