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KRIYA Ketamine Research Institute

Reading List

Here is a list of recommended readings about psychotherapeutic ketamine, organized by topic. Please think of this list as a “tasting menu” of various important aspects of therapeutic ketamine treatment. This list will be updated periodically. This website also has a list of books about psychotherapeutic ketamine, and a list of articles that cite Dr. Bennett specifically. For more info, you can find many additional articles on PubMed, and you can search for past, current and future clinical trial on ClinicalTrials.gov.


PUBLISHED GUIDELINES

American Association of Nurse Anesthesiology (2023). AANA APNA Joint Position Statement on Ketamine Infusion Therapy for Psychiatric Disorders. AANA website. 
https://www.aana.com/practice/clinical-practice/clinical-practice-resources/ketamine-infusion-therapy/

Bennett, R. (2020). Ethical guidelines for ketamine clinicians. Journal of Psychedelic Psychiatry, 2(4), 19-20.
https://www.journalofpsychedelicpsychiatry.org

McIntyre, R. S., Rosenblat, J. D., Nemeroff, C., et al. (2021). Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: An international expert opinion on the available evidence and implementation. American Journal of Psychiatry (03/17/21).
doi.org/10.1176/appi.ajp.2020.20081251

Sanacora, G., Frye, M. A., McDonald, W., et al. (2017). A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry, 74(4), 399-405. DOI: 10.1001/jamapsychiatry.2017.0080
https://adaa.org/sites/default/files/Ketamine%20JAMA%20Journal%20Article%20-%20Charlie%20Nemeroff.pdf

U.S. Food & Drug Administration (2023). FDA warns patients and health care providers about potential risks associated with compounded ketamine products, including oral formulations, for the treatment of psychiatric disorders. FDA website.
https://www.fda.gov/drugs/human-drug-compounding/fda-warns-patients-and-health-care-providers-about-potential-risks-associated-compounded-ketamine

HISTORICAL PAPERS

Bennett, R. (2019). Paradigms of ketamine treatment. MAPS Bulletin, 29(1).
https://maps.org/news/bulletin/articles/436-maps-bulletin-spring-2019-vol-29,-no-1/7718-paradigms-of-ketamine-treatment-spring-2019

Denomme, N. (2018). The Domino Effect: Ed Domino’s early studies of psychoactive drugs. Journal of Psychoactive Drugs, 50(4), 298-305. DOI: 10.1080/02791072.2018.1506599
https://www.tandfonline.com/doi/full/10.1080/02791072.2018.1506599

Diamond, P. R., Farmery, A. D., Atkinson, S., et al. (2014). Ketamine infusions for treatment resistant depression: A series of 28 patients treated weekly or twice weekly in an ECT clinic. Journal of Psychopharmacology. 28(6), 536-544.
https://doi:10.1177/0269881114527361

Dickey, H., Jenkins, D. & Butler, F.  (2012). Pre-hospital use of ketamine in battlefield analgesia. U.S. Defense Health Board.
https://apps.dtic.mil/sti/pdfs/AD1029081.pdf 

Domino, E. (1965). Taming the Ketamine Tiger. Republished in Anesthesiology (Sept 2010, vol 113), 678-684.
https://doi.org/10.1097/ALN.0b013e3181ed09a2

Oaklander, M. (2017). New hope for depression. TIME.
https://time.com/magazine/us/4876068/august-7th-2017-vol-190-no-6-u-s/

Ryan, W. C., Marta, C. J. & Koek, R. J. (2014). Ketamine and depression: A review. International Journal of Transpersonal Studies, 33(2), 40-74.
http://dx.doi.org/10.24972/ijts.2014.33.2.40

Sewell, A. (2007). Ketamine: Peril and promise. MAPS Bulletin, XVII (1). 
https://maps.org/news-letters/v17n1-html/ketamine-peril_and_promise.html

EFFICACY

Ahuja, S., Brendle, M., Smart, L. et al. (2022). Real-world depression, anxiety and safety outcomes of intramuscular ketamine treatment: A retrospective descriptive cohort study. BMC Psychiatry 22(634).
https://doi.org/10.1186/s12888-022-04268-5

Anand, A., Mathew, S. J., Sanacora, G., et al. (2023). Ketamine versus ECT for nonpsychotic treatment-resistant major depression. New England Journal of Medicine, 388(25), 2315-2325.
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2302399

Bonnett, C., Jane, R., Ross, C. et al. (2021) Intramuscular ketamine to treat major depressive disorder: A case series of forty patients. Journal of Psychiatry and Mental Health, 6, 1-4. DOI: 10.16966/2474-7769.145
https://www.sciforschenonline.org/journals/psychiatry-mental-health/article-data/JPMH145/JPMH145.pdf

Molero, P., Ramos-Quiroga, J. A., Martin-Santos, R. et al. (2018). Antidepressant efficacy and tolerability of ketamine and esketamine: A critical review. CNS Drugs 32.
https://doi.org/10.1007/s40263-018-0519-3

SAFETY PROFILE & SIDE EFFECTS & INTERACTIONS

Acevedo-Diaz, E. E., Cavanaugh, G. W., Greenstein, D., et al. (2019). Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression. Journal of Affective Disorders.
https://doi.org/10.1016/j.jad.2019.11.028

Andrashko, V., Novak, T., Bunovsky, M., et al. (2020). The antidepressant effect of ketamine is dampened by concomitant benzodiazepine medication. Frontiers in Psychiatry.
https://doi.org/10.3389/fpsyt.2020.00844

Bennett, R. & Yavorsky, C. (2021). Op-Ed: Mind the Ketamine Education Gap – Better training can prevent adverse outcomes in psychiatric patients. MedPage Today.
https://www.medpagetoday.com/psychiatry/depression/91719?trw=no

Feifel, D., Dadiomov, D., & Lee, K. (2020). ​Safety of repeated administration of parenteral ketamine for depression​. ​Pharmaceuticals, 13(7).
https://doi.org/10.3390/ph13070151

Morgan, C. J. A., & Curran, H. V. (2011). Ketamine use: A review. Addiction, 107(1), 27–38. DOI: 10.1111/j.1360-0443.2011.03576.x
https://pubmed.ncbi.nlm.nih.gov/21777321

Pal, R., Balt, S., Erowid, E., et al. (2013). Ketamine is associated with lower urinary tract signs and symptoms. Drug and Alcohol Dependence. 132(1-2), 189-194. DOI: 10.1016/j.drugalcdep.2013.02.005
https://www.sciencedirect.com/science/article/abs/pii/S0376871613000422

Short, B., Fong, J., Galvez, V., et al. (2018). Side-effects associated with ketamine use in depression: A systematic review. The Lancet Psychiatry, 5(1), 65-78. DOI: 10.1016/S2215-0366(17)30272-9.
http://www.kaimacdonald.com/wp-content/uploads/2018/04/Short-2017-common-side-effects-with-ketamine-for-depression-w.pdf

PHARMACOLOGY

Dao, R. & Aggarwal, A. (2023). Utilization of ketamine for major depression. Journal of Exploratory Research in Pharmacology, 8(4), 342-347. DOI: 10.14218/JERP.2023.00027
https://www.xiahepublishing.com/2572-5505/JERP-2023-00027

Natoli, S. (2021). The multiple faces of ketamine in anaesthesia and analgesia. Drugs in Context.
https://doi.org/10.7573/dic.2020-12-8

BRAIN IMAGING

Ionescu, D. F., Felicione, J. M., Gosai, A., et al. (2018). Ketamine-associated brain changes: A review of the neuroimaging literature. Harvard Review of Psychiatry. 26(6), 320-339. DOI: 10.1097/HRP.0000000000000179
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102096/

KETAMINE-ASSISTED PSYCHOTHERAPY

Breeksema, J. J., Niemeijer, A., Kuin, B., et al. (2022). Holding on or letting go? Patient experiences of control, context, and care in oral esketamine treatment for treatment-resistant depression: A qualitative study. Frontiers in Psychiatry, 13:948115.
https://doi.org/10.3389/fpsyt.2022.948115

Drozdz, S. J., Goel, A., McGarr, M. W., et al. (2022). Ketamine assisted psychotherapy: A systematic narrative review of the literature. Journal of Pain Research, 15, 1691–1706. DOI: 10.2147/JPR.S360733
https://www.dovepress.com/ketamine-assisted-psychotherapy-a-systematic-narrative-review-of-the-l-peer-reviewed-fulltext-article-JPR

Gold, V. & Sienknecht, E. (2020). Ketamine-assisted psychotherapy online? Psychedelic Support.
www.psychedelic.support/resources/ketamine-assisted-psychotherapy-online/

Greenway, K. T., Garel, N., Jerome, L. & Feduccia, A. (2020). Integrating psychotherapy and psychopharmacology: Psychedelic-assisted psychotherapy and other combined treatments. Expert Review of Clinical Pharmacology.
https://doi.org/10.1080/17512433.2020.1772054

Katzman, J. (2018). Rapid depression remission and the “therapeutic bends” with ketamine-assisted psychotherapy. Psychedelics Today.
https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/

Kew, B. Porter R., Douglas, K., et al. (2023). Ketamine and psychotherapy for the treatment of psychiatric disorders: Systematic review. British Journal of Psychiatry, 9(3). DOI: 10.1192/bjo.2023.53
https://www.cambridge.org/core/journals/bjpsych-open/article/ketamine-and-psychotherapy-for-the-treatment-of-psychiatric-disorders-systematic-review/97614770DE6BC7846763FE19801D412D

Kolp, E., Young, S. M., Freidman, H., et al. (2007). Ketamine-enhanced psychotherapy: Preliminary clinical observations on its effects in treating death anxiety. International Journal of Transpersonal Studies, 26(1), 1–17.
http://dx.doi.org/10.24972/ijts.2007.26.1.1

Mathai, D., Mora, V. & Garcia-Romeu, A. (2022). Toward synergies of ketamine and psychotherapy. Frontiers in Psychology.
https://www.frontiersin.org/articles/10.3389/fpsyg.2022.868103

Muscat, S. A., Hartelius, G., Crouch, C. R., & Morin, K. W. (2022). Optimized clinical strategies for treatment-resistant depression: Integrating ketamine protocols with trauma and attachment informed psychotherapy. Psychology International (Psych), 4(1), 119-141. DOI: 10.3390/psych4010012
https://www.mdpi.com/2624-8611/4/1/12

Rundel, M. (2022). Psychedelic psychoanalysis: Transformations of the self. Psychoanalytic Dialogues,32(5), 469-483.
https://doi.org/10.1080/10481885.2022.2106139

Wilkinson, S. T., Wright, D., Fasula, M. K., et al. (2017). Cognitive behavior therapy may sustain antidepressant effects of intravenous ketamine in treatment-resistant depression. Psychotherapy and Psychosomatics, 86(3), 162–167. DOI: 10.1159/000457960
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516265/

Yermus, R., Bottos, J., Bryson, N., et al. (2024). Ketamine-assisted psychotherapy provides lasting and effective results in the treatment of depression, anxiety, and post-traumatic stress disorder at 3 and 6 months. Psychedelic Medicine. DOI: 10.1089/psymed.2023.0021
https://doi.org/10.1089/psymed.2023.0021

DISSOCIATIVE & PSYCHEDELIC EXPERIENCE

Kolp, E., Friedman, H. L., Krupitsky, E., et al. (2014). Ketamine psychedelic psychotherapy: Focus on its pharmacology, phenomenology, and clinical applications. International Journal of Transpersonal Studies, 33(2), 84-140.
https://doi.org/10.24972/ijts.2014.33.2.84

Krupitsky, E. M., & Grinenko, A. Y. (1997). Ketamine psychedelic therapy (KPT): A review of the results of ten years of research. Journal of psychoactive drugs, 29(2), 165-183.
https://doi.org/10.1080/02791072.1997.10400185

Kungurtsev, I. (1991). “Death-rebirth” psychotherapy with ketamine. The Albert Hoffman Foundation Bulletin. 
http://whale.to/b/kungurtsev.html

Luckenbaugh, D. A., Niciu, M. J., Ionescu, D. F., et al. (2014). Do the dissociative side effects of ketamine mediate its antidepressant effects? Journal of Affective Disorders, 159, 56-61.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065787/

Mathai, D., Mathew, S. J., Storch, E. A., & Kosten, T. R. (2018). Revisiting the hallucinogenic potential of ketamine. Psychiatric Times, 35(6).
https://www.psychiatrictimes.com/view/revisiting-hallucinogenic-potential-ketamine

Mathai, D. S., Meyer, M. J., Storch, E. A., & Kosten, T. R. (2020). The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review. Journal of Affective Disorders, 264, 123-129.
https://doi.org/10.1016/j.jad.2019.12.023

Nice, M. J., Shovestul, B. J., Jaso, B. A., et al. (2018). Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression. Journal of Affective Disorders, 232, 310-315.
https://doi.org/10.1016/j.jad.2018.02.049

GROUP WORK 

Dames, S., Kryskow, P. & Watler, C. (2021). A cohort-based case report: The impact of ketamine-assisted psychotherapy embedded in a community of practice framework for healthcare providers with PTSD and depression. Frontiers in Psychiatry, 12. DOI: 10.3389/fpsyt.2021.803279
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.803279/full

Tsang, V. W. L., Tao, B., Dames, S., et al. (2023) Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots to Thrive ketamine-assisted therapy program: A retrospective chart review. Therapeutic Advances in Psychopharmacology, 13. DOI: 10.1177/20451253231171512
https://journals.sagepub.com/doi/full/10.1177/20451253231171512

FOR YOUNGER & OLDER PATIENTS

Cullen, K. R., Amatya, P., Roback, M. G., et al. (2018). Intravenous ketamine for adolescents with treatment-resistant depression: An open-label study. Journal of Child and Adolescent Psychopharmacology, 28(7), 437-444. DOI: 10.1089/cap.2018.0030
https://www.ncbi.nlm.nih.gov/pubmed/30004254

Gardner, C. (2017). Case report reveals successful treatment of adolescent depression with ketamine. Yale School of Medicine.
https://medicine.yale.edu/news-article/14682/

George, D., Gálvez, V., Martin, D., et al. (2017). Pilot randomized controlled trial of titrated subcutaneous ketamine in older patients with treatment-resistant depression. The American Journal of Geriatric Psychiatry, 25(7), 1199-1209. DOI: 10.1016/j.jagp.2017.06.007
https://www.sciencedirect.com/science/article/abs/pii/S1064748117303512?via%3Dihub

Papolos, D., Frei, M., Rosssigtnol, D., et al. (2018). Clinical experience using intranasal ketamine in the longitudinal treatment of juvenile bipolar disorder with fear of harm phenotype. Journal of Affective Disorders, 225, 545-551. DOI: 10.1016/j.jad.2017.08.081
https://www.sciencedirect.com/science/article/abs/pii/S0165032717305888

Turban, J. (2017). The ketamine breakthrough for suicidal children. Scientific American.
https://www.scientificamerican.com/article/the-ketamine-breakthrough-for-suicidal-children/

Zarrinnegar, P., Kothari, J., & Cheng, K. (2019). Successful use of ketamine for the treatment of psychotic depression in a teenager. Journal of Child and Adolescent Psychopharmacology, 29(6), 472-473. DOI: 10.1089/cap.2019.0028
https://www.ncbi.nlm.nih.gov/pubmed/31161948

FOR BIPOLAR DISORDER

Bahji, A., Zarate, C. A. & Vazquez, G. H. (2021). Ketamine for bipolar depression: A systematic review. International Journal of Neuropsychopharmacology, 24(7), 535–541.
https://doi.org/10.1093/ijnp/pyab023

Bennett, R., Yavorsky, C. & Bravo, G. (2022). Ketamine for bipolar depression: Biochemical, psychotherapeutic, and psychedelic approaches. Frontiers in Psychiatry, 13. DOI: 10.3389/fpsyt.2022.867484
https://www.frontiersin.org/articles/10.3389/fpsyt.2022.867484/full

Fancy, F., Rodrigues, N. B., Di Vincenzo, J. D., et al. (2023). Real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression. Bipolar Disorders.
https://onlinelibrary.wiley.com/doi/10.1111/bdi.13284

FOR POST-TRAUMATIC STRESS DISORDER (PTSD)

Halstead, M., Reed, S., Krause, R. & Williams, M. (2021). Ketamine-assisted psychotherapy for PTSD related to racial discrimination. Clinical Case Studies, 20(4), 310-330.
https://journals.sagepub.com/doi/full/10.1177/1534650121990894

Liriano, F., Hatten, C., & Schwartz, T. L. (2019). Ketamine as treatment for post-traumatic stress disorder: A review. Drugs in Context, 8(212305). DOI: 10.7573/dic.212305
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457782/

Ross, C., Jain, R., Bonnett, C. J., & Wolfson, P. (2019). High-dose ketamine infusion for the treatment of posttraumatic stress disorder in combat veterans. Annals of Clinical Psychiatry, 31(4), 271-279.
https://www.ncbi.nlm.nih.gov/pubmed/31675388

FOR OBSESSIVE-COMPULSIVE DISORDER (OCD)

Bottemanne, H., & Arnould, A. (2021). Ketamine augmentation of exposure response prevention therapy for obsessive-compulsive disorder. Innovations in clinical neuroscience, 18(10-12), 9–11.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794478/

Rodriguez, C. I., Kegeles, L. S., Flood, P., & Simpson, H. B. (2011). Rapid resolution of obsessions after an infusion of intravenous ketamine in a patient with treatment-resistant obsessive-compulsive disorder. The Journal of Clinical Psychiatry, 72(4), 567–569. DOI: 10.4088/JCP.10l06653
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727240/

Rodriguez, C. I., Wheaton, M., Zwerling, J., Steinman, S. A., Sonnenfeld, D., Galfalvy, H., & Simpson, H. (2016). Can exposure-based CBT extend the effects of intravenous ketamine in obsessive-compulsive disorder? An open-label trial. The Journal of Clinical Psychiatry, 77(3), 408–409. DOI: 10.4088/JCP.15l10138
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544939/

FOR EATING DISORDER

Calabrese, L., Scolnick, B., Zupec-Kania, B., et al. (2022). Ketogenic diet and ketamine infusion treatment to target chronic persistent eating disorder psychopathology in anorexia nervosa: A pilot study. Eating and Weight Disorders.
https://doi.org/10.1007/s40519-022-01455-x

Mills, I. H., Park, G. R., Manara, A. R. & Merriman, R. J. (1998) Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions. QJM International Journal of Medicine, 91(7), 493-503. DOI: 10.1093/qjmed/91.7.493
https://academic.oup.com/qjmed/article/91/7/493/1598067

Skolnick, B., Zupec-Kania, B., Calabrese, L., et al. (2020). Remission from chronic anorexia nervosa with ketogenic diet and ketamine. Frontiers in Psychiatry. DOI: 10.3389/fpsyt.2020.00763
https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00763/full

FOR SUBSTANCE USE DISORDERS (SUD)

Dakwar, E., Anerella, C., Hart, C. L., et al. (2014). Therapeutic infusions of ketamine: Do the psychoactive effects matter? Drug and Alcohol Dependence, 136, 153–157. DOI: 10.1016/j.drugalcdep.2013.12.019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091719/

Dakwar E., Nunes, E.V., Hart, C.L., et al. (2018) A sub-set of psychoactive effects may be critical to the behavioral impact of ketamine on cocaine use disorder: Results from a randomized, controlled laboratory study. Neuropharmacology, 142, 270-276. DOI: 10.1016/j.neuropharm.2018.01.005
https://europepmc.org/article/PMC/6033686

Dakwar, E., Nunes, E. V., Hart, C. L., et al. (2019). A single ketamine infusion combined with mindfulness-based behavioral modification to treat cocaine dependence: A randomized clinical trial. American Journal of Psychiatry, 176(11), 923-930.
https://doi.org/10.1176/appi.ajp.2019.18101123

Grabski, M., McAndrew, A., Lawn, W. et al. (2022). Adjunctive ketamine with relapse prevention-based psychological therapy in the treatment of Alcohol Use Disorder. American Journal of Psychiatry.
https://doi.org/10.1176/appi.ajp.2021.21030277 

Jones, J. L., Mateus, C. F., Malcolm, R. J., et al. (2018). Efficacy of ketamine in the treatment of substance use disorders: A systematic review. Frontiers in Psychiatry, 9, 277. DOI: 10.3389/fpsyt.2018.00277
https://pubmed.ncbi.nlm.nih.gov/30140240/

Krupitsky, E., Burakov, A., Romanova, T., et al. (2002). Ketamine psychotherapy for heroin addiction: Immediate effects and two-year follow-up. Journal of Substance Abuse Treatment, 23, 273-283. DOI: 10.1016/s0740-5472(02)00275-1
https://www.researchgate.net/publication/10978647_Ketamine_psychotherapy_for_heroin_addiction_Immediate_effects_and_two-year_follow-up

Lalanne, L., Nicot, C., Lang, J. P., et al. (2016). Experience of the use of ketamine to manage opioid withdrawal in an addicted woman: A case report. BMC Psychiatry, 16(1), 395. DOI: 10.1186/s12888-016-1112-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105239/

Rothberg, R., L., Azhari, N., Haug, N. & Dakwar, E. (2020) Mystical-type experiences occasioned by ketamine mediate its impact on at-risk drinking: Results from a randomized, controlled trial. Journal of Psychopharmacology. DOI: 10.1177/0269881120970879
https://journals.sagepub.com/doi/abs/10.1177/0269881120970879

FOR SUICIDALITY

Calabrese, L. (2019). Titrated serial ketamine infusions stop outpatient suicidality and avert ER visits and hospitalizations. International Journal of Psychiatry Research, 2(6), 1-12.
http://scivisionpub.com/pdfs/titrated-serial-ketamine-infusions-stop-outpatient-suicidality-and-avert-er-visits-and-hospitalizations-918.pdf

Grunebaum, M. F., Galfalvy, H. C., Choo, T. H., et al. (2018). Ketamine for rapid reduction of suicidal thoughts in major depression. American Journal of Psychiatry, 75(4), 327-335. DOI: 10.1176/appi.ajp.2017.17060647
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880701/pdf/nihms911567.pdf

ARKETAMINE 

Zhang, J. C., Yao, W. & Hashimoto, K. (2022). Arketamine, a new rapid-acting antidepressant: A historical review and future directions. Neuropharmacology, 218(109219).
https://doi.org/10.1016/j.neuropharm.2022.109219

ESKETAMINE

Anderson, P. (2019). FDA’s rapid approval of esketamine for severe depression questioned. Medscape.
https://www.medscape.com/viewarticle/921248

Bahji, A., Vazquez, G. H., & Zarate, C. A. (2021). Comparative efficacy of racemic ketamine and esketamine for depression: A systemic review and meta-analysis. Journal of Affective Disorders (278) 542-55. DOI: 10.1016/j.jad.2020.09.071
https://www.sciencedirect.com/science/article/pii/S016503272032766X

Bahji, A., Zarate, C. A., Vazquez, G. H. (2022). Efficacy and safety of racemic ketamine and esketamine for depression: A systematic review and meta-analysis. Expert Opinion on Drug Safety, 853-866. DOI: 10.1080/14740338.2022.2047928
https://pubmed.ncbi.nlm.nih.gov/35231204/

Nikolin, S., Rodgers, A., Schwaab, A, et al. (2023). Ketamine for the treatment of major depression: A systematic review and meta-analysis. eClinicalMedicine, vol 62. DOI: 10.1016/j.eclinm.2023.102127
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430179/pdf/main.pdf

Ramos, M. A., Boyd, W., & Alpert, M. D. (2019). Opinion: The new ketamine-based antidepressant is a rip-off; Johnson & Johnson patented a form of the psychedelic with less research and a ridiculous price tag. VICE.
https://www.vice.com/en_us/article/pajkjy/opinion-the-new-ketamine-based-antidepressant-is-a-rip-off

Ross, E. L. & Soeteman, D. I. (2020). Cost-effectiveness of esketamine nasal spray for patients with treatment-resistant depression in the United States. Psychiatric Services.
https://ps.psychiatryonline.org/doi/10.1176/appi.ps.201900625

MAIL-ORDER KETAMINE

Huet, E. (2022). Online ketamine clinics face tougher times after Covid-era boom. Bloomberg News (11/14/22).
Bloomberg 11-14-22

Love, S. (2021). Psychedelic telemedicine has arrived… What could possibly go wrong? VICE. 
https://www.vice.com/en/article/pkpp3k/psychedelic-telemedicine-has-arrived-what-could-possibly-go-wrong

Wilkinson, S. T. & Sanacora, G. (2022). Correspondence: At-home ketamine; still a lot to learn. Journal of Affective Disorders, 318, 150-151. DOI: 10.1016/j.jad.2022.08.090 — Note: This letter was submitted in response to the misleading article by Hull, Malgaroli, Gazzaley, et al (2022).
https://docs-cdn-prod.news-engineering.aws.wapo.pub/publish_document/ffc60069-e959-433d-9a9f-c69a7a582a19/published/ffc60069-e959-433d-9a9f-c69a7a582a19.pdf

EXPLODING KETAMINE INDUSTRY

Crane, M. A., DiStefano, M. J.& Moore, T. J. (2023). False or misleading claims in online direct-to-consumer ketamine advertising in Maryland. JAMA Network Open, 6(11).
https://doi.org/10.1001/jamanetworkopen.2023.42210

Busby, M. (2023). Ketamine clinics have emerged across the US; They’re already going bust. The Guardian.
https://www.theguardian.com/society/2023/apr/11/ketamine-clinics-us-business-safety-mental-health

Thielking, M. (2018). Is the ketamine boom getting out of hand? Scientific American (09/26/18).
https://www.scientificamerican.com/article/is-the-ketamine-boom-getting-out-of-hand/

ADDICTION TO KETAMINE

Friedler, D. (2023). Does the queer scene have a ketamine problem? Rolling Stone.
https://www.rollingstone.com/culture/culture-features/ketamine-queer-scene-addiction-side-effects-1234656422/

TRAINING CLINICIANS

Bennett, R. (2024). Educational pathways for psychedelic practitioners. Journal of Psychedelic Psychiatry, 6(2), 1-6. https://tinyurl.com/bennett-edu-paths

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